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About the Precision Medicine Model

Precision Medicine: Achieving the Vision of Personalized Health Outcomes
Patient selection

Until recently, if you became ill and needed medical care you were likely treated very much the same as the next patient with the same ailment: the same diagnostic tests performed, and the same treatments prescribed. You may have been fortunate with the outcome, while the next patient was not. Or you may not have received the outcome you were hoping for.

Recent advances in our understanding of our own biology and diseases have enabled a dramatically different future for medicine, focused on the individual patient, including their genetics.

At Janssen we believe that outcomes for patients need to be far better than they have been, and this can be achieved through cost-effective solutions fueled by advanced diagnostics that deliver actionable information, and world-class therapeutics.

The current model of medical care focuses on treating people once they become ill. However we now have the potential to treat individuals earlier in their disease – potentially even before the onset of symptoms – and effectively intercept and prevent disease from developing. This requires new diagnostics to detect markers of disease, or markers that predict response to treatment, that may develop in an individual, based on their genetics, their lifestyle, their environment, or a combination of these and other factors.

The Future of Medicine Is Precise1

In the near future, more patients will be treated with precision, with interventions that are specific to their unique individual needs and are:

  • Predictive: as we understand more about our biology and disease, we are detecting biomarkers that can identify individuals predisposed for certain illnesses. In time, we will become much more accurate in predicting who will develop disease, and the probable outcome of treatment
  • Preventive: if we can be predictive, then prevention becomes much more possible, if not routine. This will create a very different model of healthcare that focuses on earlier intervention, and is based on new therapeutic approaches to avoiding ill health. Diagnostic detection of people at risk of disease, whether in the near term or decades in the future, will have a significant and positive impact on how medicine is practiced
  • Precision medicinePersonalized: with our improving insights into biology and disease, we will see specific therapeutics and disease management to improve the patient’s outcome. These tailored treatments hold the promise of reduced side effects. The long-term, real-time diagnostic monitoring of outcomes will further contribute to the realization of fully personalized healthcare
  • Participatory: technology has increased our ability to communicate and share via social networks and online communities. This trend will increase, and new tools and platforms will be created that allow individuals to access information on their disease, share it with others in a similar situation, and gain insights into lifestyle and behavioral factors that empower them to take greater control of their health and manage their illness

Healthcare is expensive, with a proportion of chronically ill patients using much of the resources, and payment for today’s model is not sustainable. More efficient, personalized, precision medicine is required to ensure value for money in outcomes, as well as more effective management of healthcare resources.

Janssen is committed to focusing the best science on the discovery and development of data-driven treatments as unique as each individual. These future treatments will be based on a deep understanding of diseases, and enabled by diagnostic advances that provide actionable information for healthcare professionals, payers and the patients they serve, within the model of precision medicine.

Please view the following fictionalized case study to better understand the potential of precision medicine:

Reference:
  1. Flores M, Glusman M, et al; P4 medicine: how systems medicine will transform the healthcare sector and society; Future Medicine 2013; 10 (6): 565-576.

Precision Medicine

Precision Medicine

Donna Williams, Family
Donna Williams, Family