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Hormone Replacement Therapy (HRT) Shortages in the UK

Hormone Replacement Therapy (HRT) Shortages in the UK

As HRT shortages continue to impact patients in the UK, we wanted to provide an update on recent developments regarding the future supply of our Evorel (estradiol) range of HRT products.

The Janssen Pharmaceutical Companies of Johnson & Johnson have entered an asset purchase agreement for its Evorel range of products (SYSTEN/EVOREL/EVOPAD patches, including the Conti and Sequi presentations) to Theramex HQ UK Limited, who have an established history in women’s health. This divestment is part of our ongoing review of our portfolio as we look to continue to bring forward transformational medicines for patients. We want to emphasise that the agreement with Theramex is not the cause or the reason for the current shortage of the Evorel range.

Theramex has been working with suppliers to shorten the manufacturing timelines, and accelerate supply to bring the product back to market earlier than originally planned. They currently anticipate the product range will be back in stock by February 2020. In the interim, we still expect product shortages, but are working with Theramex to make Evorel accessible to patients as quickly as possible.

In addition, we will continue to work closely with the UK Health Authorities, healthcare professionals and the British Menopause Society during this transition. 

For patients with questions regarding current or alternative HRT therapies during this time, we advise speaking to your GP or healthcare professional.

For pharmacists and healthcare professionals who are having difficulty obtaining supply of the Evorel range of products through wholesale providers, please contact our Customer Services team: [email protected].

If your enquiry is related to an adverse event, please contact our Drug Safety Department on 01494 567447 or by e-mail at: [email protected]

The Janssen UK team


The Janssen UK team Evorel range of products supply interruption update as of 13th November 2019:

The table below provides further detail on the latest projected supply interruption dates across the Evorel range of products as of 13th November 2019. Please note these are projections only based on current demand and remaining Janssen stock levels. There is a possibility some local pharmacies may experience shortages prior to these dates depending on ongoing demand.

Patch description                    Latest projected Janssen UK stock out dates (as of 13th November 2019)

Evorel Conti 24x1                          Out Of Stock

Evorel Conti 8x1                            21st November 2019

Evorel Sequi 8x1                            Out of Stock

Evorel 50MCG 24x1                      Out of Stock

Evorel 50MCG 8x1                        Out of Stock*

Evorel 25MCG 8x1                        27th November 2019*

Evorel 100 MCG 8x1                     Out of Stock

Evorel 75 MCG 8x1                        Out of Stock

*Please note that stock will be available at a wholesale level following Janssen stock out, until supply is exhausted






Job Code: CP-124157              Date of preparation: November 2019