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Hormone Replacement Therapy (HRT) Shortages in the UK

Hormone Replacement Therapy (HRT) Shortages in the UK

As HRT shortages continue to impact patients in the UK, we wanted to provide an update on recent developments regarding the future supply of our Evorel (estradiol) range of HRT products.

The Janssen Pharmaceutical Companies of Johnson & Johnson have entered an asset purchase agreement for its Evorel range of products (SYSTEN/EVOREL/EVOPAD patches, including the Conti and Sequi presentations) to Theramex HQ UK Limited. Theramex has a well-established history in women’s health and we believe this agreement will help ensure the long-term availability of these products for the patients who use them.  We want to emphasise that the agreement with Theramex is not the cause or the reason for the current shortage of the Evorel range.

Theramex has been working with suppliers to shorten the manufacturing timelines, and accelerate supply to bring the product back to market earlier than originally planned. They currently anticipate the product range will be back in stock from February 2020 onwards.

We will continue to work closely with the UK Health Authorities, healthcare professionals and the British Menopause Society during this transition.

For the latest information on supply of the Evorel range of products and timelines, please visit:

For patients with questions regarding current or alternative HRT therapies during this time, we advise speaking to your GP or healthcare professional.

If your enquiry is related to an adverse event associated with a Janssen product, please contact our Drug Safety Department on 01494 567447 or by e-mail at: [email protected]

The Janssen UK team


The Janssen UK team Evorel range of products supply interruption update as of 13th December 2019:

Patch description                    Latest projected Janssen UK stock out dates (as of 13th December 2019)

Evorel Conti 24x1                          Out Of Stock

Evorel Conti 8x1                            Out Of Stock

Evorel Sequi 8x1                            Out of Stock

Evorel 50MCG 24x1                      Out of Stock

Evorel 50MCG 8x1                        Out of Stock

Evorel 25MCG 8x1                        Out of stock*

Evorel 100 MCG 8x1                     Out of Stock

Evorel 75 MCG 8x1                        Out of Stock

*Please note that stock may be available at a wholesale level following Janssen stock out, until supply is exhausted






Job Code: CP-131426          Date of preparation: December 2019