One in every four people will go on to develop a neurological or mental disorder at some stage in life 1. Despite advances in our understanding of neurological and mental disorders, improving treatments and care remains challenging due to the complexity and diversity of conditions, and gaps in research of the biological basis of these disorders. Neurological and mental disorders, such as depression, dementia, and schizophrenia, can be experienced in isolation, or as co-morbidities of other conditions 1,2 . In addition to physical and psychological symptoms, they may also affect employment and education, relationships, health and overall quality of life 3. People living with these conditions often experience negative consequences from the stigma that exists in society, and the burden not only affects patients, but also their families, loved ones and caregivers.
At Janssen, we are focused on pushing the boundaries of medicine- to help resolve some of the most challenging medical conditions of our time. Mental health has been an important part of our heritage since our company was founded and we remain committed to reducing the burden, disability and devastation caused by mental health disorders.
We continue to invest in expanding treatment options, even as many companies have moved away from neuroscience because of its complexity and risk. We are immensely proud of the many ground-breaking mental health products Janssen has pioneered over the course of our 60+ year legacy in field.
Schizophrenia is a disorder of the mind that affects how you think, feel and behave. Often described as a type of psychosis, meaning people living with schizophrenia may not always be able to distinguish their own thoughts and ideas from reality 4. It causes a range of different psychological symptoms, including hallucinations, delusions, muddled thoughts, and changes in behaviour. About 1 in 100 people will suffer an episode of schizophrenia at some point during their life 4.
Major Depressive Disorder (MDD) is a is a debilitating disease and a severe form of depression, which is characterised by depressed mood (e.g. sadness, feelings of guilt or low self-worth) diminished interests, and impaired cognitive and physical function, such as disturbed sleep or appetite 5,6. People with MDD may also have multiple physical complaints with no apparent physical cause 6. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime5. Depression is a common mental disorder and one of the main causes of disability worldwide 6.
Dementia is a general term used to describe a loss of memory that keeps getting worse - or is 'progressive'. Dementia is common, and affects around 850,000 people in the UK 7. There can be many different causes, they will all involve loss of memory, but they have other symptoms which are different according to the cause 7. Common symptoms include difficulty planning and carrying out day-to-day tasks, difficulty communicating, and changes in mood, judgement or personality 7. Alzheimer’s Disease is the most common cause of dementia and accounts for about 7 in 10 of all dementias. In Alzheimer's, damaged tissue seems to build up in the brain to form deposits called 'plaques' and 'tangles' 7.
1. World Health Organisation: Mental and Neurological Disorders Fact Sheet. The World Health Report 2001.
2. Sartorious N.(2013) Comorbidity of mental and physical diseases: a main challenge for medicine of the 21st century. Shanghai Arch Psychiatry. 25(2), 68–69.
3. Connell J et al (2012). Quality of life of people with mental health problems: a synthesis of qualitative research. Health and Quality of Life Outcomes, 10, 138.
4. Royal College of Psychiatrists: Schizophrenia.
5. Otte C et al. (2016) Major depressive disorder. Nature Reviews Disease Primers volume 2, Article number: 16065.
6. World Health Organisation: Mental Disorders.
7. Royal College of Psychiatrists: Dementia and Memory Problems.