We envision a world where cancer is a preventable, chronic or curable disease. To get there, we’re focused on pursuing new pathways that can help to prolong and improve patient lives.
In Oncology, our goal is to fundamentally alter the way cancer is understood, diagnosed, and managed. One of the innovative ways that we approach this challenge is via cancer interception. We are striving to achieve a more robust understanding of the mechanisms underlying the transition of normal cells to a pre-malignant state, with the goal of developing products capable of intercepting cancer at its earliest stages, when patients are healthier and more likely to benefit.
Multiple myeloma is a blood cancer that develops when DNA is damaged during the development of plasma cells. At any one time there are around 17,500 people living with myeloma in the UK 2. Myeloma affects multiple places in the body where bone marrow is normally active in an adult, such as in the bones of the spine, skull and pelvis.
Chronic lymphocytic leukaemia (CLL) is a type of blood cancer in which the bone marrow produces too many lymphocytes (a type of white blood cell). The causes of CLL are unclear; however it is the most common type of leukaemia in adults, with around one in 200 people developing CLL at some point in their lifetime 3.
Mantle cell lymphoma (MCL) is an aggressive, chronic and incurable disease caused by a rare type of B-cell non-hodgkin lymphoma, in which the body makes abnormal B-cells called lymphoma cells and is an aggressive, chronic and incurable disease. The lymphoma cells build up in lymph nodes such as the neck, armpit or groin, which makes them bigger.
Diffuse large b-cell lymphoma (DLBCL) is the most common type of fast-growing non-hodgkin lymphoma (NHL), which develops from abnormal production of B-cells. It can occur at any age, including in children, but the risk increases with age 4.
Waldenström macroglobulinemia (WM) – is a type of non-hodgkin lymphoma in which the cancer cells make large amounts macroglobulin. Although rare, more than 400 patients are diagnosed each year in the UK 5. Because waldenström’s macroglobulinaemia can develop slowly, most people have no symptoms until they are diagnosed with advanced stages of the disease.
Prostate Cancer is the most common cancer in men and can develop when cells in the prostate grow in an uncontrollable way. In the UK, over 47,000 men are diagnosed each year 6. In certain men, prostate cancer can grow slowly and may never cause any problems, but in some cases prostate cancer can spread beyond the prostate to other areas of the body.
Urothelial Cancer or bladder cancer is where tumours develop in the inner lining of the bladder, and in some cases, spreads into the bladder muscle 7. Bladder cancer is commonly separated into slow-growing, non-invasive cancers and fast-growing invasive cancers. Every year over 10,000 people are diagnosed 8.
Lung Cancer occurs when abnormal cells divide in an uncontrollable way to form tumours in the lung or airways 9 . There are two main types of lung cancer – non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) – and the main symptoms are a cough, breathlessness and weight loss. There are around 46,300 new lung cancer cases each year in the UK and approximately 35,600 lung cancer deaths 10.
1. Cancer Facts. World Health Organization
2. What is Myeloma? Myeloma UK
3. Chronic Lymphocytic Leukaemia (CLL) Booklet. Bloodwise
4. Diffuse Large B-cell Lymphoma. Lymphoma Action
5. What is Waldenstrom Macroglobulinemia? WMUK
6. What is Prostate Cancer? Prostate Cancer UK
7. Bladder Cancer. NHS UK
8. Learn: Key Facts. Fight Bladder Cancer UK
9. About Lung Cancer. Cancer Research UK
10. Lung Cancer Incidence. Cancer Research UK