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Cáncer de pulmón new

Cáncer de pulmón
Descubre en esta página más sobre el cáncer de pulmón. Haz clic en cada pestaña y conoce a detalle, datos sobre su sintomatología, fases de la enfermedad, opciones de tratamiento, entre otros.

Este contenido se proporciona únicamente con fines informativos y no pretende ser un sustituto del concepto médico ofrecido por un profesional calificado del cuidado de la salud.
¿Qué es?
Alteraciones Genéticas
Mutaciones de inserción del Exón 20
 
Referencias

1. American Cancer Society. What is Lung Cancer? Accessed January 2021. https://www.cancer.org/cancer/lungcancer/about/what-is.html
2. World Health Organization. Cancer Fact Sheet. January 2021. https://www.who.int/news-room/fact-sheets/detail/cancer
3. Latin America and the Caribbean – Global Cancer Observatory. Globocan 2020. Acceso: 18 de agosto del 2021: https://gco.iarc.fr/today/data/factsheets/populations/904-latin-america-...
 
Referencias

4. Feng Y, et al. Exploratory analysis of introducing next-generation sequencing-based method to treatment- naive lung cancer patients. J Thorac Dis. 2018;10:5904-5912.
5. Pinherio A, et al. Using Metaphors to Explain Molecular Testing to Cancer Patients. Oncologist. 2017 Apr;22(4):445-449. doi: 10.1634/theoncologist.2016-0270. Epub 2017 Feb 20.
6. Jordan E, et al. Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies. Cancer Discov. 7(6); 596–609.
7. Zhang Y, et al. The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis. Oncotarget. 2016 Nov 29; 7(48): 78985–78993.
8. Raez LE, Cardona AF, Santos ES, Catoe H, Rolfo C, Lopes G, Barrios C, Mas LA, Vallejos C, Zatarain-Barrón ZL, Caglevic C, Arrieta O. La carga del cáncer de pulmón en América Latina y los desafíos en el acceso al perfil genómico, la inmunoterapia y los tratamientos dirigidos. Cáncer de pulmón. 2018 mayo; 119:7-13. doi: 10.1016/j.lungcan. 2018.02.014. Epub 2018 mar 2. PMID: 29656755.
9. Vyse S, Huang PH. Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer. Sig Transduct Target Ther. 4, 5 (2019). 10. Riess JW, Gandar DR, Frampton GM, et al. Diverse EGFR Exon 20 insertions and co-occurring molecular alterations identified by comprehensive genomic of NSCLC. J Thorac Oncol. 2018;13(10):1560-1568. 10.1016/j. jtho.2018.06.019.
11. Arcila M, et al. EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics. Molecular Cancer Therapeutics. 2013; Feb; 12(2):220-9.
12. Dersarkissian M, Bhak R, Lin H, et al. P2.01-103 Real-world treatment patterns and survival in non-small cell lung cancer patients with EGFR Exon 20 insertion mutations. J Thorac Oncol. 2019;14(10)(suppl S681). doi:10.1016/j.-jtho.2019.08.1446
13. Ramalingam SS, Vansteenkiste J, Planchard D, et al. Overall survival with osimertinib in untreated, EGFR- mutated advanced NSCLC. N Engl J Med. 2020;382(1):41-50. doi:10.1056/NEJMoa1913662
14. Oxnard JR, et al. Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 Insertions. J Thorac Oncol. 2013 Feb;8(2):179-84. doi: 10.1097/JTO.0b013e3182779d18.
 
Referencias

10. Riess JW, Gandar DR, Frampton GM, et al. Diverse EGFR Exon 20 insertions and co-occurring molecular alterations identified by comprehensive genomic of NSCLC. J Thorac Oncol. 2018;13(10):1560-1568. 10.1016/j. jtho.2018.06.019.
13. Ramalingam SS, Vansteenkiste J, Planchard D, et al. Overall survival with osimertinib in untreated, EGFR- mutated advanced NSCLC. N Engl J Med. 2020;382(1):41-50. doi:10.1056/NEJMoa1913662
15. Pennell NA, Mutebi A, Zhou Z, et al. Economic impact of next-generation sequencing versus single-gene testing to detect genomic alterations in metastatic non–small-cell lung cancer using a decision analytic model. JCO Precision Oncol. Published online May 16, 2019.
16. Chen D, Song Z, Cheng G. Clinical efficacy of first-generation EGFR-TKIs in patients with advanced non-small-cell lung cancer harboring EGFR exon 20 mutations. Onco Targets Ther. 2016;9:4181-4186
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